Self driven microfluidic filter for seperating liquid from a liquid including deformable particles. MKT2021/0174_H
This Novel Microfluidic blood plasma filter has been design and validated in MicroTechLab of the Mechanical Engineering Department of UPC. Currently, partners to combine the System with a diagnostic tool and batch produce it and/or to establish commercial agreements along with technical cooperation are thought. Ref. MKT2021/0174_H
Self driven microfluidic filter for seperating liquid from a liquid including deformable particles. MKT2021/0174_H
This Novel Microfluidic blood plasma filter has been design and validated in MicroTechLab of the Mechanical Engineering Department of UPC. Currently, partners to combine the System with a diagnostic tool and batch produce it and/or to establish commercial agreements along with technical cooperation are thought. Ref: MKT2021/0174_H
El repte/The challenge
Nowadays, there is a growing need for lab-on-chip devices especially in clinical analysis and diagnostics. First step in most blood assays is plasma extraction from whole blood. Compared to traditional centrifugation processes ”lab-on-a-chip” devices minimize the manipulation errors, reduce the time from blood collection to the test and provide faster and yet less expensive and comprehensive results since the amount of sample and reagents are drastically reduced. Although many researchers have developed plasma separation from whole blood utilizing different techniques, the volume of extracted plasma and the separation time are the two main barriers to implement the current commercial test on microfluidic platforms.
La tecnologia/The technology
This patent presents a novel high throughput blood plasma separation microfluidic chip, designed and fabricated to be used as first step in a point-of-care Device to maximize the amount of plasma extracted from a single blood droplet. Hydrodynamic behaviour of red blood cells in a constriction channel is the base for plasma extraction using a symmetric cross flow filtration MIMP (Microchannel Integrated Micro-Pillars) channel together with electrokinetic techniques are used to maximize the amount of extracted plasma and minimize the time required for a complete separation.
Avantatges innovadores/Innovative advantages
The presented microdevice has several advantages
- Maximized amount of extracted plasma (approx. 15% initial volume)
- Outstanding purity (approx. 99%)
- Minimized required time (less than 3 minutes)
- Multiple assay integration in a single microfluidic chip
Fase actual de desenvolupament/Current stage of development
Prototypes have been developed and tested.
An industrial manufacturing process is defined.
Aplicacions i mercat objectiu/Applications and target market
Clinical Laboratories and In Vitro Diagnostic Industry.
Picture 1: iBlood micromachined channels
Picture 2: Comparison with a regular lateral flow assay which uses 4 times more sample
Oportunitats de negoci/Business opportunity
Tecnologia disponible per a ser llicenciada/Technology available to be licensed
Estat de la propietat intel·lectual i industrial/Intelectual property status
Patent aprovada/Approved patent
Contacte/Contact
Servei de Gestió de la Innovació
T. +34 934 13 76 23
gestio.innovacio@upc.edu