Nanoenabled Hydrogels for Advanced Skin Care : SKinGEL. MKT2021/0182_H
A new method for in situ self-assembling of NPs with phenolic-shell and biopolymers with nucleophilic groups into multifunctional nanocomposite hydrogel for enhancing wound closure and tissue recovery (Skingel). Ref. MKT2021/0182_H
Nanoenabled Hydrogels for Advanced Skin Care : SKinGEL. MKT2021/0182_H
A new method for in situ self-assembling of NPs with phenolic-shell and biopolymers with nucleophilic groups into multifunctional nanocomposite hydrogel for enhancing wound closure and tissue recovery (Skingel). Ref: MKT2021/0182_H
El repte/The challenge
Chemically crosslinked hydrogel networks are formed by non-reversible covalent bonds between the polymer chains. Generally, this crosslinking is achieved by redox reactions, radical polymerisation, photo-polymerisation, click chemistry, Michael addition, Schiff’s base reactions or enzymes. In spite of showing good mechanical performance for a wide range of applications, the utilization of toxic catalysts or crosslinkers, and harsh conditions is a major drawback that makes them unsuitable for biomedical applications. The selfassembling occurs under mild conditions, avoiding the use of harsh chemicals and thereby is suitable for a preparation of materials with wide range of medical applications. Selfassembled hydrogels demonstrate high biocompatibility and can be explored for the in situ incorporation of bioactive agents and cells within the matrix. Up to date, most of the selfassembled hydrogels possess poor mechanical properties, or require costly and hardly scalable synthesis of the components, which have limited their application in biomedical engineering.
La tecnologia/The technology
- SKinGEL are biopolymer hydrogels for advanced skin care targeting multiple factors in skin pathologies, such as deleterious enzyme activities, bacterial load and reactive oxygen species.
- The versatile nanoparticle (NP)-driven self-assembling technology of SKinGEL uses metalphenolic NPs as bioactive and structural element in biocompatible, self-healing and injectable hydrogel matrices.
- SKinGEL is validated for treatment of chronic wounds ex-vivo in wound exudates and in vivo in diabetic and non-diabetic animal models showing complete tissue remodeling and restoration of skin integrity.
- The engineered nano-enabled hydrogels are also ideal candidates for cell-based and drug delivery therapies, tissue engineering and regenerative medicine applications.
Avantatges innovadores/Innovative advantages
- SKinGEL answers the unmet need for efficient multifunctional skin care materials to improve patients’ quality of life.
- SKinGEL is a (bio)nanotechnology-embedded skin care product providing a holistic therapeutic approach towards healthy skin.
Fase actual de desenvolupament/Current stage of development
Laboratory validation. It’s required a pre-clinical validation.
Aplicacions i mercat objectiu/Applications and target market
Fast self-assessment (Rapid Diagnostic Kit) / Point-of-care (PoC) tests for infection in-out hospital conditions, performed by patients suffering from:
- Chronic wounds
- Chronic obstructive pulmonary disease (COPD)
- Adverse cardiac events
Oportunitats de negoci/Business opportunity
Tecnologia disponible per a ser llicenciada amb cooperació tècnica/Technology available to be licensed with technical cooperation
Estat de la propietat intel·lectual i industrial/Intelectual property status
Altres formes de protecció/Other forms of protection
Contacte/Contact
Servei de Gestió de la Innovació
T. +34 934 13 76 23
gestio.innovacio@upc.edu